Evidence of mitochondrial nitrosative damage and energy stress behind omega‐6 PUFA induced cardiac dysfunction
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چکیده
منابع مشابه
Mitochondrial injury and dysfunction in hypertension-induced cardiac damage.
Hypertension remains an important modifiable risk factor for cardiovascular disease, associated with increased morbidity and mortality. Deciphering the mechanisms involved in the pathogenesis of hypertension is critical, as its prevalence continues increasing worldwide. Mitochondria, the primary cellular energy producers, are numerous in parenchymal cells of the heart, kidney, and brain, major ...
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Ide, Shunji Hayashidani, Tetsuya Shiomi, Toru Kubota, Naotaka Hamasaki and Akira Nobuhiro Suematsu, Hiroyuki Tsutsui, Jing Wen, Dongchon Kang, Masaki Ikeuchi, Tomomi Damage and Dysfunction in Cardiac Myocytes Induced Mitochondrial DNA − α Oxidative Stress Mediates Tumor Necrosis FactorPrint ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2003 American Heart Association, Inc. All rights rese...
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BACKGROUND Tumor necrosis factor-alpha (TNF-alpha) and angiotensin II (Ang II) are implicated in the development and further progression of heart failure, which might be, at least in part, mediated by the production of reactive oxygen species (ROS). However, the cause and consequences of this agonist-mediated ROS production in cardiac myocytes have not been well defined. Recently, we demonstrat...
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Mitochondria are indispensable for bioenergetics and for the regulation of physiological/signaling events in cellular life. Although TNF-alpha-induced oxidative stress and mitochondrial dysfunction are evident in several pathophysiological states, the molecular mechanisms coupled with impaired cardiac function and its potential reversal by drugs such as Tempol or apocyanin have not yet been exp...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a186